Non-Invasive Pre-Implantation Genetic Testing in Hyderabad

The journey to parenthood can be filled with anticipation, but for many couples, infertility can become a significant emotional and physical challenge. Thanks to advancements in reproductive science, cutting-edge techniques like Non-Invasive Pre-Implantation Genetic Testing (niPGT) are revolutionizing fertility care. This advanced method allows for genetic screening of embryos without invasive procedures, helping couples increase the success rates of IVF treatments while ensuring the health of their future child. At Fertilica IVF, we offer Non-Invasive Pre-Implantation Genetic Testing Treatment in Hyderabad, providing hopeful parents with a safe, accurate, and embryo-friendly genetic diagnostic option.

What is Non-Invasive Pre-Implantation Genetic Testing?

Non-Invasive Pre-Implantation Genetic Testing (niPGT) is a state-of-the-art screening method used during in-vitro fertilization (IVF) to evaluate the chromosomal health of embryos without the need to extract cells from them. Unlike traditional PGT-A (Preimplantation Genetic Testing for Aneuploidy), which involves biopsying a few cells from the embryo, niPGT analyses the cell-free DNA (cfDNA) released into the culture medium by the embryo itself. This genetic diagnosis offers a less risky, non-invasive, and equally accurate way to detect chromosomal abnormalities, which can cause miscarriage, failed implantation, or inherited genetic disorders.

How Does niPGT Work?

During IVF, embryos are cultured in a special medium in the laboratory. As embryos grow and develop, they naturally release DNA fragments into this medium. With niPGT, these DNA fragments are collected from the culture media and analyzed using next-generation sequencing (NGS) to determine if the embryo has the correct number of chromosomes. This method provides insight into the embryo's genetic makeup without disturbing or damaging the embryo itself, making it ideal for identifying genetically healthy embryos for implantation.

Advantages of Non-Invasive Pre-Implantation Genetic Testing

Non-Invasive Pre-Implantation Genetic Testing is for infertility management and offers several advantages over traditional biopsy-based genetic screening:

• No Risk to Embryo: Since the embryo is not biopsied, there is no mechanical interference, ensuring its full integrity and developmental potential.
• Improved IVF Success Rates: Selecting chromosomally normal embryos improves the chances of successful implantation and live birth.
• Reduced Miscarriage Risk: Screening helps avoid transferring embryos with abnormalities that could lead to miscarriage.
• Ethically Preferred: Since no tissue is removed, niPGT is considered more ethical by many patients and clinicians.
• Compatible with Blastocyst Culture: Works seamlessly with Day 5 blastocyst embryos, which are already being widely used in advanced IVF clinics.

Why Choose Non-Invasive Pre-Implantation Genetic Testing in Hyderabad?

Hyderabad is emerging as a major hub for advanced fertility treatments, and Fertilica IVF stands at the forefront of this medical revolution. Couples looking for Non-Invasive Pre-Implantation Genetic Testing Treatment in Hyderabad find Fertilica IVF to be a trusted choice due to our state-of-the-art labs, experienced fertility specialists, and personalized patient care. Our clinic combines the latest advancements in genetic diagnosis with world-class IVF protocols to maximize your chances of a healthy pregnancy while maintaining the highest safety standards.

Who Should Consider niPGT?

Non-Invasive PGT is particularly beneficial for:

• Women over 35 who face increased risks of chromosomal abnormalities
• Couples with a history of recurrent miscarriages
• Patients with multiple failed IVF cycles
• Those seeking a safer alternative to traditional embryo biopsy
• Couples with known chromosomal translocations or genetic risks
• Patients pursuing elective single embryo transfer to avoid multiple pregnancies

Choosing the healthiest embryo is critical in IVF, and niPGT enables informed embryo selection without any invasive intervention.

Genetic Diagnosis Without Compromise

Traditional genetic screening methods like PGT-A, PGT-M (monogenic diseases), and PGT-SR (structural rearrangements) have proven invaluable in improving IVF outcomes. However, concerns about embryo damage and ethical considerations have driven the development of non-invasive genetic diagnosis methods. With niPGT, patients can access highly accurate genetic information without compromising embryo quality. This approach supports both medical precision and the moral comfort of many patients.

The niPGT Procedure Step-by-Step

Embryo Culture: Embryos are grown in a controlled lab environment up to the blastocyst stage (Day 5 or Day 6).
Collection of Culture Media: The fluid in which the embryo was grown is collected, containing cfDNA released by the embryo.
DNA Extraction and Amplification: Advanced techniques extract and amplify DNA fragments to ensure sufficient quantity and quality for sequencing.
Genetic Analysis: Using high-throughput sequencing, chromosomal abnormalities such as trisomies or monosomies are identified.
Embryo Selection: Based on results, genetically normal embryos are selected for transfer.
This comprehensive process is performed with rigorous quality controls, ensuring reliable outcomes.

Success Rates and Accuracy of niPGT

The accuracy of niPGT has improved significantly over the years. Studies now suggest that niPGT offers around 85–90% concordance with invasive biopsy-based PGT-A methods. While it may not fully replace traditional biopsy methods in all scenarios, its high sensitivity and specificity make it an effective choice for many patients. At Fertilica IVF, our expertise in embryology and genetic testing ensures that patients receive the most accurate diagnosis and optimal embryo selection possible.

Integrating niPGT with IVF at Fertilica IVF

At Fertilica IVF, we integrate Non-Invasive Pre-Implantation Genetic Testing into your IVF journey without adding stress or complexity. Here’s how we streamline the process:

• Pre-IVF Evaluation: We begin with fertility assessment and counsel you on the role of genetic testing.
• Embryo Culture Optimization: Our embryologists use specialized media and protocols that maximize cfDNA yield.
• Rapid Turnaround: Results are typically available within 48–72 hours after blastocyst development, ensuring no delay in embryo transfer.
• Personalized Guidance: Genetic counselors and fertility experts review test results with you, helping you make informed decisions.

Ethical and Emotional Benefits of niPGT

For many couples, the decision to proceed with genetic screening is a deeply personal one. The non-invasive nature of niPGT provides emotional reassurance, allowing them to move forward with confidence and peace of mind. It aligns with the values of patients who are concerned about embryo integrity and long-term outcomes. Moreover, avoiding embryo biopsy may ease the emotional burden of the IVF process, especially for first-time parents or those who have faced challenges with previous attempts.

Comparing niPGT and Traditional PGT

Cost of Non-Invasive Pre-Implantation Genetic Testing in Hyderabad

The cost of niPGT in Hyderabad varies depending on the clinic, lab facilities, and integration with your IVF cycle. On average, the cost is slightly lower than that of traditional PGT-A due to the avoidance of biopsy-related procedures. At Fertilica IVF, we believe in transparent pricing and offer cost-effective packages that include niPGT as part of our advanced fertility treatments. Our focus is on maximizing your success rate while minimizing emotional and financial stress.

Future of Genetic Testing in IVF

As technology continues to advance, non-invasive methods like niPGT are expected to become the standard of care. Ongoing research is improving accuracy, reducing costs, and expanding the scope of detectable conditions. At Fertilica IVF, we are committed to staying at the forefront of these innovations to offer our patients the best possible outcomes.

Schedule Your Consultation Today

If you're exploring options for Non-Invasive Pre-Implantation Genetic Testing in Hyderabad, Fertilica IVF is here to support you every step of the way. Our team of fertility experts, embryologists, and genetic counselors will provide the guidance, care, and cutting-edge solutions you need to achieve your dream of parenthood. Contact us today to schedule a personalized consultation and take the first step toward a healthy, successful pregnancy—powered by science and delivered with compassion.